{"id":2289,"date":"2022-02-17T15:38:31","date_gmt":"2022-02-17T06:38:31","guid":{"rendered":"http:\/\/kanka.cmes.ehime-u.ac.jp\/en\/?p=2289"},"modified":"2022-02-17T15:38:31","modified_gmt":"2022-02-17T06:38:31","slug":"contamination-status-and-development-of-risk-assessment-of-ionic-environmental-pollutants-in-brain","status":"publish","type":"post","link":"http:\/\/kanka.cmes.ehime-u.ac.jp\/en\/research\/2289.html","title":{"rendered":"Contamination status and development of risk assessment  of ionic environmental pollutants in brain"},"content":{"rendered":"<p>Ionic environmental pollutants have been linked to low bio-persistence and bioaccumulation. However, they are detected in various organisms and induce neurotoxicity and abnormal behavior at the environmental exposure level because of the development of analytical techniques, so academic and social interest is focused on the transferability to the brain and risk assessment.<\/p>\n<p>In order to evaluate the effects of exposure to ionic environmental pollutants, we study the analysis of endogenous hormones and neurotransmitters using mass spectrometry (GC-\/MS. LC-MS\/MS, and LC-QToF-MS\/MS), and the development of endpoints using the metabolomics method for target samples such as brain and serum. Additionally, we elucidate the \u201ccommonality\u201d and \u201cspecies difference\u201d that lead to the mechanism of neurotoxicity by integrating with ADME and omics analysis for various organism species.<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-medium wp-image-2290\" src=\"http:\/\/kanka.cmes.ehime-u.ac.jp\/en\/contents\/wp-content\/uploads\/2022\/02\/52970862f1d0a8313aa930b9b96aef25-300x278.jpg\" alt=\"\" width=\"300\" height=\"278\" srcset=\"http:\/\/kanka.cmes.ehime-u.ac.jp\/en\/contents\/wp-content\/uploads\/2022\/02\/52970862f1d0a8313aa930b9b96aef25-300x278.jpg 300w, http:\/\/kanka.cmes.ehime-u.ac.jp\/en\/contents\/wp-content\/uploads\/2022\/02\/52970862f1d0a8313aa930b9b96aef25-560x518.jpg 560w, http:\/\/kanka.cmes.ehime-u.ac.jp\/en\/contents\/wp-content\/uploads\/2022\/02\/52970862f1d0a8313aa930b9b96aef25-768x711.jpg 768w, http:\/\/kanka.cmes.ehime-u.ac.jp\/en\/contents\/wp-content\/uploads\/2022\/02\/52970862f1d0a8313aa930b9b96aef25-1536x1422.jpg 1536w, http:\/\/kanka.cmes.ehime-u.ac.jp\/en\/contents\/wp-content\/uploads\/2022\/02\/52970862f1d0a8313aa930b9b96aef25-2048x1896.jpg 2048w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Ionic environmental pollutants have been linked to low bio-persistence and bioaccumulation. However, they are  [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[16],"tags":[],"class_list":["post-2289","post","type-post","status-publish","format-standard","hentry","category-research"],"acf":[],"_links":{"self":[{"href":"http:\/\/kanka.cmes.ehime-u.ac.jp\/en\/wp-json\/wp\/v2\/posts\/2289","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/kanka.cmes.ehime-u.ac.jp\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/kanka.cmes.ehime-u.ac.jp\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/kanka.cmes.ehime-u.ac.jp\/en\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"http:\/\/kanka.cmes.ehime-u.ac.jp\/en\/wp-json\/wp\/v2\/comments?post=2289"}],"version-history":[{"count":1,"href":"http:\/\/kanka.cmes.ehime-u.ac.jp\/en\/wp-json\/wp\/v2\/posts\/2289\/revisions"}],"predecessor-version":[{"id":2291,"href":"http:\/\/kanka.cmes.ehime-u.ac.jp\/en\/wp-json\/wp\/v2\/posts\/2289\/revisions\/2291"}],"wp:attachment":[{"href":"http:\/\/kanka.cmes.ehime-u.ac.jp\/en\/wp-json\/wp\/v2\/media?parent=2289"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/kanka.cmes.ehime-u.ac.jp\/en\/wp-json\/wp\/v2\/categories?post=2289"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/kanka.cmes.ehime-u.ac.jp\/en\/wp-json\/wp\/v2\/tags?post=2289"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}