Ionic environmental pollutants have been linked to low bio-persistence and bioaccumulation. However, they are detected in various organisms and induce neurotoxicity and abnormal behavior at the environmental exposure level because of the development of analytical techniques, so academic and social interest is focused on the transferability to the brain and risk assessment.

In order to evaluate the effects of exposure to ionic environmental pollutants, we study the analysis of endogenous hormones and neurotransmitters using mass spectrometry (GC-/MS. LC-MS/MS, and LC-QToF-MS/MS), and the development of endpoints using the metabolomics method for target samples such as brain and serum. Additionally, we elucidate the “commonality” and “species difference” that lead to the mechanism of neurotoxicity by integrating with ADME and omics analysis for various organism species.