A wide variety of bioactive compounds in pharmaceutical, personal care, and household products have been found in global surface water and aquatic organisms, which has raised concern about their potential adverse effects on aquatic ecosystems. Since physiological/biological effects of chemicals are triggered when their concentrations in the organism exceeds the respective threshold values, understanding of bioconcentration, toxicokinetics (uptake/absorption, distribution, metabolism, and excretion), and toxicodynamics of bioactive compounds in aquatic organisms is important to address interspecies differences in sensitivity to environmental contaminants.

We have studied on [1] development of sensitive methods for the simultaneous determination of synthetic bioactive compounds in surface water and aquatic organisms, [2] examination of bioconcentration and toxicokinetics of bioactive compounds, [3] ecological risk assessment of bioactive compounds, and [4] exploration of toxicokinetic parameters causing high bioconcentration potential in aquatic organisms and their interspecies differences.

In addition, we have recently started a comprehensive micropollutant analysis with liquid chromatography quadrupole time-of-flight mass spectrometry (LC-QToF-MS/MS) to detect unregulated novel synthetic chemicals with bioaccumulative and ecotoxic